Research workbench
Structure of an SGT1-SKP1 complex
Analyse Structure of an SGT1-SKP1 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5AN3
- Type
- protein
- Length
- 504 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SGT1; Suppressor of kinetochore protein 1
- UniProt
- Q08446, P52286
- Pockets
- 7 · best druggability 0.58
Structure
x-ray diffraction · 4 distinct chains · 74% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SGT1 | protein | 130 | 80% helix, 0% strand | Q08446 |
| B | SGT1 | protein | 136 | 80% helix, 0% strand | Q08446 |
| C | SGT1 | protein | 135 | 79% helix, 0% strand | Q08446 |
| D | Suppressor of kinetochore protein 1 | protein | 103 | 54% helix, 13% strand | P52286 |
Pockets
7 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 202 | 0.58 | 0.80 | 29 | empty |
| 2 | 152 | 0.55 | 0.81 | 25 | empty |
| 3 | 203 | 0.54 | 0.78 | 22 | empty |
| 4 | 151 | 0.54 | 0.80 | 20 | empty |
| 5 | 201 | 0.52 | 0.77 | 30 | empty |
Interfaces
4 interfaces between chains.
- C–D · 659 Ų buried · 7 hydrogen bonds · protein-protein
- A–B · 658 Ų buried · 8 hydrogen bonds · protein-protein
- A–C · 641 Ų buried · 9 hydrogen bonds · protein-protein
- B–C · 73 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 5AN3 · Structure of an Sgt1-Skp1 Complex · the same entry in another collection · chain D against D, TM-score 1.00
- Q08446 · AlphaFold monomer V2.0 prediction for protein SGT1 (Q08446) · a predicted model of the same protein · chain B against A, TM-score 0.99
- P52286 · AlphaFold monomer V2.0 prediction for suppressor of kinetochore protein 1 (P52286) · a predicted model of the same protein · chain D against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q08446
- Every structure of UniProt P52286
- Elsewhere: RCSB PDB 5AN3 · PDBe 5AN3 · UniProt Q08446 · UniProt P52286
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