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Uncomplexed des 1-6 bovine neurophysin

Analyse Uncomplexed des 1-6 bovine neurophysin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1JK6
Type: protein
Length: 160 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Neurophysin 2
UniProt: P01180
Pockets: 2 · best druggability 0.35

Structure

x-ray diffraction · 1 distinct chain · 21% helix, 41% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C	Neurophysin 2	protein	80	21% helix, 41% strand	P01180

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	77	0.35	0.76	18	empty
2	77	0.33	0.75	18	empty

Interfaces

1 interface between chains.

A–C · 581 Å² buried · 11 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 14 disulfide (disulfide).

Compared structures

1JK6 · Uncomplexed des 1-6 bovine neurophysin · the same entry in another collection · chain C against C, TM-score 1.00
P01180 · AlphaFold monomer V2.0 prediction for vasopressin-neurophysin 2-copeptin (P01180) · a predicted model of the same protein · chain A against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01180
Elsewhere: RCSB PDB 1JK6 · PDBe 1JK6 · UniProt P01180

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