Research workbench
Human papillomavirus type 18 E2 DNA-binding domain bound to its DNA target
Analyse Human papillomavirus type 18 E2 DNA-binding domain bound to its DNA target in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1JJ4
- Type
- protein + DNA
- Length
- 182 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- E2 binding site DNA; Regulatory protein E2
- UniProt
- P06790
- Pockets
- 1 · best druggability 0.44
Structure
x-ray diffraction · 3 distinct chains · 35% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C, D | E2 binding site DNA | dna | 16 | — | — |
| A | Regulatory protein E2 | protein | 74 | 34% helix, 38% strand | P06790 |
| B | Regulatory protein E2 | protein | 76 | 36% helix, 34% strand | P06790 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 92 | 0.44 | 0.80 | 22 | empty |
Interfaces
6 interfaces between chains.
- A–B · 840 Ų buried · 20 hydrogen bonds · protein-protein
- C–D · 726 Ų buried · 57 hydrogen bonds · nucleic-nucleic
- C–A · 374 Ų buried · 11 hydrogen bonds · protein-nucleic
- D–B · 367 Ų buried · 12 hydrogen bonds · protein-nucleic
- C–B · 289 Ų buried · 5 hydrogen bonds · protein-nucleic
Compared structures
- 1JJ4 · Human papillomavirus type 18 E2 DNA-binding domain bound to its DNA target · the same entry in another collection · chain C against C, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06790
- Elsewhere: RCSB PDB 1JJ4 · PDBe 1JJ4 · UniProt P06790
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