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Tetrameric assembly of lgn with inscuteable

Analyse Tetrameric assembly of lgn with inscuteable in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5A7D
Type: protein
Length: 5,065 residues
Chains: 16
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pins; Inscuteable
UniProt: Q9VB22, Q24367
Pockets: 20 · best druggability 0.86

Structure

x-ray diffraction · 15 distinct chains · 78% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Pins	protein	354	84% helix, 0% strand	Q9VB22
C	Pins	protein	348	82% helix, 0% strand	Q9VB22
D	Pins	protein	345	83% helix, 0% strand	Q9VB22
E	Pins	protein	352	83% helix, 0% strand	Q9VB22
F, I	Pins	protein	346	83% helix, 0% strand	Q9VB22
G	Pins	protein	346	85% helix, 0% strand	Q9VB22
H	Pins	protein	347	85% helix, 0% strand	Q9VB22
L	Inscuteable	protein	284	71% helix, 0% strand	Q24367
M	Inscuteable	protein	259	73% helix, 0% strand	Q24367
N	Inscuteable	protein	283	74% helix, 0% strand	Q24367
O	Inscuteable	protein	288	73% helix, 0% strand	Q24367
P	Inscuteable	protein	288	71% helix, 0% strand	Q24367
Q	Inscuteable	protein	281	72% helix, 0% strand	Q24367
R	Inscuteable	protein	311	70% helix, 0% strand	Q24367
S	Inscuteable	protein	287	74% helix, 0% strand	Q24367

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1092	0.86	0.87	124	empty
2	813	0.83	0.86	90	empty
3	913	0.82	0.84	86	empty
4	572	0.81	0.87	56	empty
5	340	0.77	0.88	58	empty

Interfaces

33 interfaces between chains.

C–M · 2685 Å² buried · 40 hydrogen bonds · protein-protein
I–S · 2669 Å² buried · 37 hydrogen bonds · protein-protein
D–N · 2593 Å² buried · 38 hydrogen bonds · protein-protein
G–Q · 2567 Å² buried · 36 hydrogen bonds · protein-protein
H–R · 2558 Å² buried · 35 hydrogen bonds · protein-protein

Compared structures

5A7D · Tetrameric assembly of LGN with Inscuteable · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9VB22
Every structure of UniProt Q24367
Elsewhere: RCSB PDB 5A7D · PDBe 5A7D · UniProt Q9VB22 · UniProt Q24367

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