Research workbench
Crystal structure of the CTP1L endolysin reveals how its activity is regulated by a secondary translation product
Analyse Crystal structure of the CTP1L endolysin reveals how its activity is regulated… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5A6S
- Type
- protein
- Length
- 352 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Endolysin
- UniProt
- D9ZNF3
- Ligands
- SO4
- Pockets
- 3 · best druggability 0.63
Structure
x-ray diffraction · 2 distinct chains · 35% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Endolysin | protein | 273 | 34% helix, 26% strand | D9ZNF3 |
| B | Endolysin | protein | 79 | 37% helix, 20% strand | D9ZNF3 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · chains A
- GOL · Glycerol · additive · 3 copies · chains A, B
- 1PE · Pentaethylene glycol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 356 | 0.63 | 0.78 | 34 | empty |
| 2 | 64 | 0.37 | 0.78 | 16 | empty |
| 3 | 79 | 0.35 | 0.76 | 19 | SO4 |
Interfaces
1 interface between chains.
- A–B · 801 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 5A6S · Crystal structure of the CTP1L endolysin reveals how its activity is regulated by a… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt D9ZNF3
- Elsewhere: RCSB PDB 5A6S · PDBe 5A6S · UniProt D9ZNF3
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