Research workbench
Crystal structure of the btb domain of human KCTD17
Analyse Crystal structure of the btb domain of human KCTD17 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5A6R
- Type
- protein
- Length
- 507 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- BTB/POZ domain-containing protein KCTD17
- UniProt
- Q8N5Z5
- Pockets
- 6 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 42% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | BTB/POZ domain-containing protein KCTD17 | protein | 102 | 42% helix, 16% strand | Q8N5Z5 |
| B, D, E | BTB/POZ domain-containing protein KCTD17 | protein | 101 | 42% helix, 16% strand | Q8N5Z5 |
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1110 | 0.71 | 0.75 | 103 | empty |
| 2 | 122 | 0.43 | 0.76 | 18 | empty |
| 3 | 116 | 0.42 | 0.76 | 19 | empty |
| 4 | 113 | 0.41 | 0.76 | 20 | empty |
| 5 | 101 | 0.41 | 0.77 | 19 | empty |
Interfaces
8 interfaces between chains.
- D–E · 808 Ų buried · 16 hydrogen bonds · protein-protein
- C–E · 791 Ų buried · 16 hydrogen bonds · protein-protein
- B–C · 790 Ų buried · 18 hydrogen bonds · protein-protein
- A–B · 787 Ų buried · 16 hydrogen bonds · protein-protein
- A–D · 756 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 5A6R · Crystal structure of the BTB domain of human KCTD17 · the same entry in another collection · chain D against D, TM-score 1.00
- Q8N5Z5 · AlphaFold monomer V2.0 prediction for BTB/POZ domain-containing protein KCTD17 (Q8N5Z5) · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8N5Z5
- Elsewhere: RCSB PDB 5A6R · PDBe 5A6R · UniProt Q8N5Z5
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