Research workbench
Cryo-EM structure of the SLO2.2 na-activated K channel
Analyse Cryo-EM structure of the SLO2.2 na-activated K channel in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5A6F
- Type
- protein
- Length
- 583 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gating ring of potassium channel subfamily T member 1; RCK2 elaboration of potassium…
- UniProt
- Q8QFV0
- Pockets
- 11 · best druggability 0.77
Structure
electron microscopy · 2 distinct chains · 34% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | Gating ring of potassium channel subfamily T member 1 | protein | 540 | 31% helix, 17% strand | Q8QFV0 |
| D | RCK2 elaboration of potassium channel subfamily T member 1 | protein | 43 | 65% helix, 0% strand | — |
Pockets
11 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 107 | 0.77 | 0.96 | 27 | empty |
| 2 | 392 | 0.63 | 0.78 | 53 | empty |
| 3 | 51 | 0.58 | 0.91 | 17 | empty |
| 4 | 65 | 0.54 | 0.87 | 22 | empty |
| 5 | 52 | 0.53 | 0.88 | 16 | empty |
Interfaces
1 interface between chains.
- C–D · 223 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 5A6F · Cryo-EM structure of the Slo2.2 Na-activated K channel · the same entry in another collection · chain C against C, TM-score 1.00
- Q8QFV0 · AlphaFold monomer V2.0 prediction for potassium channel subfamily T member 1 (Q8QFV0) · a predicted model of the same protein · chain C against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8QFV0
- Elsewhere: RCSB PDB 5A6F · PDBe 5A6F · UniProt Q8QFV0
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