Research workbench
Cryo-EM structure of the SLO2.2 na-activated K channel
Analyse Cryo-EM structure of the SLO2.2 na-activated K channel in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5A6E
- Type
- protein
- Length
- 816 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- S1-S4 domain of potassium channel subfamily T member 1; Pore domain of potassium channel…
- UniProt
- Q8QFV0
- Pockets
- 16 · best druggability 0.75
Structure
electron microscopy · 4 distinct chains · 48% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | S1-S4 domain of potassium channel subfamily T member 1 | protein | 139 | 85% helix, 0% strand | — |
| B | Pore domain of potassium channel subfamily T member 1 | protein | 94 | 81% helix, 0% strand | Q8QFV0 |
| C | Gating ring of potassium channel subfamily T member 1 | protein | 540 | 31% helix, 17% strand | Q8QFV0 |
| D | RCK2 elaboration of potassium channel subfamily T member 1 | protein | 43 | 65% helix, 0% strand | — |
Pockets
16 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 90 | 0.75 | 0.96 | 20 | empty |
| 2 | 51 | 0.64 | 0.94 | 17 | empty |
| 3 | 157 | 0.59 | 0.83 | 28 | empty |
| 4 | 170 | 0.59 | 0.83 | 36 | empty |
| 5 | 338 | 0.59 | 0.77 | 42 | empty |
Interfaces
3 interfaces between chains.
- C–D · 222 Ų buried · 0 hydrogen bonds · protein-protein
- A–C · 60 Ų buried · 0 hydrogen bonds · protein-protein
- B–C · 37 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 5A6E · Cryo-EM structure of the Slo2.2 Na-activated K channel · the same entry in another collection · chain A against A, TM-score 1.00
- Q8QFV0 · AlphaFold monomer V2.0 prediction for potassium channel subfamily T member 1 (Q8QFV0) · a predicted model of the same protein · chain C against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8QFV0
- Elsewhere: RCSB PDB 5A6E · PDBe 5A6E · UniProt Q8QFV0
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