Research workbench
Crystal structure of the lotus domain (aa 139-222) of drosophila oskar in C222
Analyse Crystal structure of the lotus domain (aa 139-222) of drosophila oskar in C222 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5A49
- Type
- protein
- Length
- 735 residues
- Chains
- 10
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Maternal effect protein oskar
- UniProt
- P25158
- Pockets
- 10 · best druggability 0.74
Structure
x-ray diffraction · 9 distinct chains · 42% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, I | Maternal effect protein oskar | protein | 75 | 44% helix, 15% strand | P25158 |
| B | Maternal effect protein oskar | protein | 74 | 43% helix, 15% strand | P25158 |
| C | Maternal effect protein oskar | protein | 77 | 44% helix, 14% strand | P25158 |
| D | Maternal effect protein oskar | protein | 60 | 30% helix, 17% strand | P25158 |
| E | Maternal effect protein oskar | protein | 74 | 39% helix, 15% strand | P25158 |
| F | Maternal effect protein oskar | protein | 75 | 43% helix, 15% strand | P25158 |
| G | Maternal effect protein oskar | protein | 73 | 42% helix, 12% strand | P25158 |
| H | Maternal effect protein oskar | protein | 76 | 42% helix, 14% strand | P25158 |
| J | Maternal effect protein oskar | protein | 76 | 45% helix, 14% strand | P25158 |
Pockets
10 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1152 | 0.74 | 0.77 | 85 | empty |
| 2 | 796 | 0.72 | 0.77 | 50 | empty |
| 3 | 742 | 0.69 | 0.76 | 46 | empty |
| 4 | 575 | 0.65 | 0.76 | 45 | empty |
| 5 | 151 | 0.41 | 0.74 | 20 | empty |
Interfaces
17 interfaces between chains.
- B–C · 720 Ų buried · 16 hydrogen bonds · protein-protein
- H–J · 645 Ų buried · 5 hydrogen bonds · protein-protein
- F–G · 637 Ų buried · 14 hydrogen bonds · protein-protein
- A–C · 629 Ų buried · 5 hydrogen bonds · protein-protein
- H–I · 628 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 5A49 · Crystal structure of the LOTUS domain (aa 139-222) of Drosophila Oskar in C222 · the same entry in another collection · chain J against J, TM-score 1.00
- P25158 · AlphaFold monomer V2.0 prediction for maternal effect protein oskar (P25158) · a predicted model of the same protein · chain J against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P25158
- Elsewhere: RCSB PDB 5A49 · PDBe 5A49 · UniProt P25158
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