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Crystal structure of calcium-free human adseverin domains A1-A3

Analyse Crystal structure of calcium-free human adseverin domains A1-A3 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5A1K
Type: protein
Length: 681 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Adseverin
UniProt: Q9Y6U3
Pockets: 11 · best druggability 0.76

Structure

x-ray diffraction · 2 distinct chains · 23% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Adseverin	protein	341	23% helix, 29% strand	Q9Y6U3
B	Adseverin	protein	340	23% helix, 30% strand	Q9Y6U3

Pockets

11 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	984	0.76	0.79	139	empty
2	192	0.74	0.90	26	empty
3	171	0.53	0.79	23	empty
4	127	0.51	0.80	25	empty
5	154	0.50	0.78	21	empty

Interfaces

1 interface between chains.

A–B · 981 Å² buried · 17 hydrogen bonds · protein-protein

Compared structures

5A1K · Crystal structure of calcium-free human adseverin domains A1-A3 · the same entry in another collection · chain A against A, TM-score 1.00
Q9Y6U3 · AlphaFold monomer V2.0 prediction for adseverin (Q9Y6U3) · a predicted model of the same protein · chain A against A, TM-score 0.90

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9Y6U3
Elsewhere: RCSB PDB 5A1K · PDBe 5A1K · UniProt Q9Y6U3

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