Research workbench
Crystal structure of methylated sulfolobus solfataricus O6- methylguanine methyltransferase
Analyse Crystal structure of methylated sulfolobus solfataricus O6- methylguanine… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4ZYG
- Type
- protein
- Length
- 300 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Methylated-DNA--protein-cysteine methyltransferase
- EC
- 2.1.1.63
- UniProt
- Q97VW7
- Pockets
- 2 · best druggability 0.65
Structure
x-ray diffraction · 2 distinct chains · 35% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) | protein | 151 | 36% helix, 17% strand | Q97VW7 |
| B | Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) | protein | 149 | 34% helix, 19% strand | Q97VW7 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 356 | 0.65 | 0.79 | 33 | empty |
| 2 | 71 | 0.32 | 0.75 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 469 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide, 2 modified (disulfide, methylation).
Compared structures
- 4ZYG · Crystal structure of methylated Sulfolobus solfataricus O6-methylguanine methyltransferase · the same entry in another collection · chain A against A, TM-score 1.00
- Q97VW7 · AlphaFold monomer V2.0 prediction for methylated-DNA--protein- cysteine methyltransferase… · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q97VW7
- Elsewhere: RCSB PDB 4ZYG · PDBe 4ZYG · UniProt Q97VW7
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