Research workbench

K. lactis LST4 longin domain

Analyse K. lactis LST4 longin domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4ZY8
Type: protein
Length: 579 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein LST4
UniProt: Q6CXP4
Pockets: 4 · best druggability 0.76

Structure

x-ray diffraction · 4 distinct chains · 43% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
C	Protein LST4	protein	144	41% helix, 26% strand	Q6CXP4
A	Protein LST4	protein	146	42% helix, 28% strand	Q6CXP4
B	Protein LST4	protein	144	46% helix, 28% strand	Q6CXP4
D	Protein LST4	protein	145	43% helix, 29% strand	Q6CXP4

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	890	0.76	0.79	85	empty
2	66	0.49	0.84	16	empty
3	125	0.45	0.77	17	empty
4	50	0.43	0.84	21	empty

Interfaces

5 interfaces between chains.

C–B · 583 Å² buried · 3 hydrogen bonds · protein-protein
C–D · 527 Å² buried · 7 hydrogen bonds · protein-protein
B–D · 404 Å² buried · 3 hydrogen bonds · protein-protein
A–D · 278 Å² buried · 1 hydrogen bond · protein-protein
C–A · 125 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

4ZY8 · K. lactis Lst4 longin domain · the same entry in another collection · chain D against D, TM-score 1.00
Q6CXP4 · AlphaFold monomer V2.0 prediction for protein LST4 (Q6CXP4) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6CXP4
Elsewhere: RCSB PDB 4ZY8 · PDBe 4ZY8 · UniProt Q6CXP4

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.