Research workbench
Purine repressor mutant corepressor binding domain structure
Analyse Purine repressor mutant corepressor binding domain structure in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1JHZ
- Type
- protein
- Length
- 552 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Purine nucleotide synthesis repressor
- UniProt
- P0ACP7
- Ligands
- MG
- Pockets
- 5 · best druggability 0.76
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Purine nucleotide synthesis repressor | protein | 276 | 41% helix, 18% strand | P0ACP7 |
Ligands and binding sites
- MG · Magnesium ion · metal · 3 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 969 | 0.76 | 0.78 | 78 | MG |
| 2 | 195 | 0.55 | 0.79 | 24 | empty |
| 3 | 170 | 0.47 | 0.76 | 27 | empty |
| 4 | 80 | 0.44 | 0.80 | 15 | empty |
| 5 | 63 | 0.33 | 0.76 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 1685 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 1JHZ · Purine Repressor Mutant Corepressor Binding Domain Structure · the same entry in another collection · chain A against A, TM-score 1.00
- P0ACP7 · AlphaFold monomer V2.0 prediction for hth-type transcriptional repressor purr (P0ACP7) · a predicted model of the same protein · chain A against A, TM-score 0.85
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0ACP7
- Elsewhere: RCSB PDB 1JHZ · PDBe 1JHZ · UniProt P0ACP7
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