Research workbench
Neurospora crassa cobalamin-independent methionine synthase complexed with CD2+
Analyse Neurospora crassa cobalamin-independent methionine synthase complexed with CD2+ in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4ZTY
- Type
- protein
- Length
- 768 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cobalamin-independent methionine synthase
- EC
- 2.1.1.14
- UniProt
- Q8X1E4
- Ligands
- CD, NO3
- Pockets
- 7 · best druggability 0.82
Structure
x-ray diffraction · 1 distinct chain · 47% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cobalamin-independent methionine synthase (EC 2.1.1.14) | protein | 768 | 47% helix, 14% strand | Q8X1E4 |
Ligands and binding sites
- CD · Cadmium ion · metal · 6 copies · chains A
- NO3 · Nitrate ion · ion · 2 copies · chains A
- GOL · Glycerol · additive · 2 copies · chains A
- TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 797 | 0.82 | 0.85 | 104 | CD, TRS |
| 2 | 52 | 0.70 | 0.98 | 20 | empty |
| 3 | 188 | 0.56 | 0.80 | 26 | empty |
| 4 | 192 | 0.55 | 0.79 | 29 | empty |
| 5 | 113 | 0.43 | 0.77 | 23 | empty |
Compared structures
- 4ZTY · Neurospora crassa cobalamin-independent methionine synthase complexed with Cd2+ · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8X1E4
- Elsewhere: RCSB PDB 4ZTY · PDBe 4ZTY · UniProt Q8X1E4
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