Research workbench
Three-dimensional structure of a heteroclitic antigen- antibody cross-reaction complex
Analyse Three-dimensional structure of a heteroclitic antigen- antibody cross-reaction… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1JHL
- Type
- protein
- Length
- 353 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- IGG1-kappa D11.15 fv (light chain); IGG1-kappa D11.15 fv (heavy chain); Pheasant egg…
- UniProt
- P00702
- Pockets
- 5 · best druggability 0.66
Structure
x-ray diffraction · 3 distinct chains · 16% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | IGG1-kappa D11.15 fv (light chain) | protein | 108 | 0% helix, 48% strand | — |
| H | IGG1-kappa D11.15 fv (heavy chain) | protein | 116 | 5% helix, 52% strand | — |
| A | Pheasant egg white lysozyme | protein | 129 | 40% helix, 11% strand | P00702 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 132 | 0.66 | 0.88 | 25 | empty |
| 2 | 184 | 0.45 | 0.75 | 23 | empty |
| 3 | 61 | 0.29 | 0.74 | 17 | empty |
| 4 | 60 | 0.27 | 0.73 | 17 | empty |
| 5 | 57 | 0.27 | 0.73 | 14 | empty |
Interfaces
3 interfaces between chains.
- L–H · 788 Ų buried · 4 hydrogen bonds · protein-protein
- H–A · 473 Ų buried · 6 hydrogen bonds · protein-protein
- L–A · 241 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 1JHL · Three-dimensional structure of a heteroclitic antigen-antibody cross-reaction complex · the same entry in another collection · chain L against L, TM-score 1.00
- P00702 · AlphaFold monomer V2.0 prediction for lysozyme C (P00702) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00702
- Elsewhere: RCSB PDB 1JHL · PDBe 1JHL · UniProt P00702
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