Research workbench

Dcsbis, a diguanylate cyclase from pseudomonas aeruginosa

Analyse Dcsbis, a diguanylate cyclase from pseudomonas aeruginosa in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4ZMU
Type: protein
Length: 1,355 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Diguanylate cyclase
UniProt: Q9I072
Pockets: 14 · best druggability 0.83

Structure

x-ray diffraction · 2 distinct chains · 42% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Diguanylate cyclase	protein	341	42% helix, 24% strand	Q9I072
B, C, D	Diguanylate cyclase	protein	338	43% helix, 24% strand	Q9I072

Pockets

14 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1033	0.83	0.84	101	empty
2	778	0.80	0.83	77	empty
3	537	0.77	0.84	52	empty
4	580	0.76	0.83	55	empty
5	647	0.69	0.77	57	empty

Interfaces

3 interfaces between chains.

C–D · 1644 Å² buried · 17 hydrogen bonds · protein-protein
A–B · 1603 Å² buried · 9 hydrogen bonds · protein-protein
B–C · 535 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

4ZMU · Dcsbis, a diguanylate cyclase from Pseudomonas aeruginosa · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9I072
Elsewhere: RCSB PDB 4ZMU · PDBe 4ZMU · UniProt Q9I072

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.