Research workbench
Crystal structure analysis of kelch protein (with disulfide bond) from plasmodium falciparum
Analyse Crystal structure analysis of kelch protein (with disulfide bond) from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4ZGC
- Type
- protein
- Length
- 745 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Kelch protein
- UniProt
- A0A077LQB4
- Ligands
- UNX
- Pockets
- 9 · best druggability 0.79
Structure
x-ray diffraction · 2 distinct chains · 10% helix, 40% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Kelch protein | protein | 372 | 10% helix, 39% strand | A0A077LQB4 |
| B | Kelch protein | protein | 373 | 10% helix, 41% strand | A0A077LQB4 |
Ligands and binding sites
- UNX · Unknown atom or ion · ion · 36 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1040 | 0.79 | 0.81 | 89 | UNX |
| 2 | 514 | 0.77 | 0.85 | 41 | empty |
| 3 | 125 | 0.46 | 0.78 | 31 | UNX |
| 4 | 108 | 0.46 | 0.79 | 23 | UNX |
| 5 | 59 | 0.45 | 0.84 | 17 | UNX |
Interfaces
1 interface between chains.
- A–B · 1282 Ų buried · 16 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 4ZGC · Crystal Structure Analysis of Kelch protein (with disulfide bond) from Plasmodium… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A077LQB4
- Elsewhere: RCSB PDB 4ZGC · PDBe 4ZGC · UniProt A0A077LQB4
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