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Crystal structure of EIF2B beta from chaetomium thermophilum

Analyse Crystal structure of EIF2B beta from chaetomium thermophilum in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4ZEM
Type: protein
Length: 626 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Translation initiation factor EIF2B-like protein, translation initiation factor…
UniProt: G0SEE6
Pockets: 7 · best druggability 0.64

Structure

x-ray diffraction · 2 distinct chains · 55% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Translation initiation factor EIF2B-like protein, translation initiation factor EIF2B-like protein	protein	328	55% helix, 13% strand	G0SEE6
B	Translation initiation factor EIF2B-like protein, translation initiation factor EIF2B-like protein	protein	298	55% helix, 15% strand	G0SEE6

Pockets

7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	424	0.64	0.78	53	empty
2	198	0.51	0.77	28	empty
3	121	0.50	0.80	28	empty
4	149	0.49	0.78	27	empty
5	211	0.44	0.73	37	empty

Interfaces

1 interface between chains.

A–B · 646 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

4ZEM · Crystal structure of eIF2B beta from Chaetomium thermophilum · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt G0SEE6
Elsewhere: RCSB PDB 4ZEM · PDBe 4ZEM · UniProt G0SEE6

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