Crystal structure of the ring finger domain of SLX1 in complex with the C-terminal domain of SLX4

Structure

x-ray diffraction · 3 distinct chains · 33% helix, 13% strand (DSSP).

Ligands and binding sites

• ZN · Zinc ion · metal · 4 copies · chains A, C
• SO4 · Sulfate ion · ion · chains D
• GOL · Glycerol · additive · 5 copies · chains B, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

3 interfaces between chains.

• A–B · 770 Ų buried · 8 hydrogen bonds · protein-protein
• C–D · 767 Ų buried · 5 hydrogen bonds · protein-protein
• A–C · 437 Ų buried · 11 hydrogen bonds · protein-protein

Compared structures

• 4ZDT · Crystal structure of the RING finger domain of Slx1 in complex with the C-terminal domain… · the same entry in another collection · chain A against A, TM-score 1.00
• Q9P6M0 · AlphaFold monomer V2.0 prediction for structure-specific endonuclease subunit SLX4… · a predicted model of the same protein · chain B against A, TM-score 0.94
• Q9P7M3 · AlphaFold monomer V2.0 prediction for structure-specific endonuclease subunit SLX1… · a predicted model of the same protein · chain A against A, TM-score 0.85

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9P7M3
• Every structure of UniProt Q9P6M0
• Elsewhere: RCSB PDB 4ZDT · PDBe 4ZDT · UniProt Q9P7M3 · UniProt Q9P6M0