Research workbench
Crystal structure of the M. tuberculosis CTP synthase pyrg in complex with two UTP molecules
Analyse Crystal structure of the M. tuberculosis CTP synthase pyrg in complex with two… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4ZDJ
- Type
- protein
- Length
- 535 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- CTP synthase
- EC
- 6.3.4.2
- UniProt
- P9WHK7
- Ligands
- UTP, MG
- Pockets
- 5 · best druggability 0.75
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | CTP synthase (EC 6.3.4.2) | protein | 535 | 41% helix, 22% strand | P9WHK7 |
Ligands and binding sites
- UTP · Uridine 5'-triphosphate · ligand · 2 copies · chains A
- MG · Magnesium ion · metal · 2 copies · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 131 | 0.75 | 0.94 | 23 | GOL |
| 2 | 55 | 0.49 | 0.86 | 15 | empty |
| 3 | 202 | 0.47 | 0.75 | 25 | UTP, MG |
| 4 | 69 | 0.39 | 0.79 | 15 | empty |
| 5 | 67 | 0.30 | 0.74 | 19 | empty |
Compared structures
- 4ZDJ · Crystal structure of the M. tuberculosis CTP synthase PyrG in complex with two UTP… · the same entry in another collection · chain A against A, TM-score 1.00
- P9WHK7 · AlphaFold monomer V2.0 prediction for CTP synthase (P9WHK7) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P9WHK7
- Elsewhere: RCSB PDB 4ZDJ · PDBe 4ZDJ · UniProt P9WHK7
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.