Research workbench
Structure of a transglutaminase 2-specific autoantibody Fab fragment
Analyse Structure of a transglutaminase 2-specific autoantibody Fab fragment in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4ZD3
- Type
- protein
- Length
- 404 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 679-14-14E06 Fab fragment heavy chain; 679-14-14E06 Fab fragment light chain
- Pockets
- 2 · best druggability 0.52
Structure
x-ray diffraction · 2 distinct chains · 5% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | 679-14-14E06 Fab fragment heavy chain | protein | 199 | 6% helix, 50% strand | — |
| L | 679-14-14E06 Fab fragment light chain | protein | 205 | 3% helix, 50% strand | — |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 289 | 0.52 | 0.74 | 41 | empty |
| 2 | 66 | 0.29 | 0.73 | 19 | empty |
Interfaces
1 interface between chains.
- H–L · 1733 Ų buried · 17 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 4ZD3 · Structure of a transglutaminase 2-specific autoantibody Fab fragment · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 4ZD3 · PDBe 4ZD3
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.