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2.2 ångström crystal structure of a human arginyl-tRNA synthetase

Analyse 2.2 ångström crystal structure of a human arginyl-tRNA synthetase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4ZAJ
Type: protein
Length: 577 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Arginine--tRNA ligase, cytoplasmic
EC: 6.1.1.19
UniProt: P54136
Pockets: 9 · best druggability 0.62

Structure

x-ray diffraction · 1 distinct chain · 54% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Arginine--tRNA ligase, cytoplasmic (EC 6.1.1.19)	protein	577	54% helix, 12% strand	P54136

Pockets

9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	312	0.62	0.79	38	empty
2	132	0.57	0.83	20	empty
3	141	0.55	0.81	21	empty
4	162	0.53	0.79	21	empty
5	50	0.46	0.85	15	empty

Compared structures

4ZAJ · 2.2 Angstrom Crystal Structure of a Human Arginyl-tRNA Synthetase · the same entry in another collection · chain A against A, TM-score 1.00
P54136 · AlphaFold monomer V2.0 prediction for arginine--tRNA ligase, cytoplasmic (P54136) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P54136
Elsewhere: RCSB PDB 4ZAJ · PDBe 4ZAJ · UniProt P54136

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