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Crystal structure of CAS6B
Analyse Crystal structure of CAS6B in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4Z7L
- Type
- protein + RNA
- Length
- 1,233 residues
- Chains
- 9
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- CAS6B; RNA (5'-R(*GP*CP*AP*AP*AP*AP*UP*AP*AP*CP*AP*AP*GP*C)-3')
- UniProt
- A4FXZ3
- Ligands
- SO4
- Pockets
- 17 · best druggability 0.61
Structure
x-ray diffraction · 5 distinct chains · 23% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D, G | CAS6B | protein | 218 | 25% helix, 36% strand | A4FXZ3 |
| B | CAS6B | protein | 193 | 22% helix, 34% strand | A4FXZ3 |
| E | CAS6B | protein | 170 | 22% helix, 32% strand | A4FXZ3 |
| H | CAS6B | protein | 174 | 23% helix, 37% strand | A4FXZ3 |
| C, F, I | RNA (5'-R(*GP*CP*AP*AP*AP*AP*UP*AP*AP*CP*AP*AP*GP*C)-3') | rna | 14 | — | — |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 3 copies · chains A, C, D, F, G, I
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
17 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 445 | 0.61 | 0.76 | 43 | empty |
| 2 | 178 | 0.61 | 0.83 | 28 | empty |
| 3 | 192 | 0.56 | 0.79 | 29 | empty |
| 4 | 63 | 0.54 | 0.88 | 19 | empty |
| 5 | 116 | 0.48 | 0.79 | 22 | empty |
Interfaces
12 interfaces between chains.
- D–F · 1385 Ų buried · 41 hydrogen bonds · protein-nucleic
- A–C · 1323 Ų buried · 34 hydrogen bonds · protein-nucleic
- G–I · 1300 Ų buried · 35 hydrogen bonds · protein-nucleic
- G–H · 759 Ų buried · 16 hydrogen bonds · protein-protein
- A–B · 672 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 4Z7L · Crystal structure of Cas6b · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A4FXZ3
- Elsewhere: RCSB PDB 4Z7L · PDBe 4Z7L · UniProt A4FXZ3
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