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Crystal structure of multidrug resistant HIV-1 protease clinical isolate PR20D25N with open flap

Analyse Crystal structure of multidrug resistant HIV-1 protease clinical isolate… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4Z4X
Type: protein
Length: 198 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protease
UniProt: Q0PQ60
Pockets: 1 · best druggability 0.59

Structure

x-ray diffraction · 1 distinct chain · 7% helix, 54% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Protease	protein	99	7% helix, 54% strand	Q0PQ60

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	505	0.59	0.73	48	empty

Interfaces

1 interface between chains.

A–B · 1563 Å² buried · 34 hydrogen bonds · protein-protein

Compared structures

4Z4X · Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical Isolate PR20D25N with… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q0PQ60
Elsewhere: RCSB PDB 4Z4X · PDBe 4Z4X · UniProt Q0PQ60

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