Research workbench
Crystal structure of the ferm-SH2 domains of JAK2
Analyse Crystal structure of the ferm-SH2 domains of JAK2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4Z32
- Type
- protein
- Length
- 3,396 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein kinase JAK2
- EC
- 2.7.10.2
- UniProt
- O60674
- Pockets
- 20 · best druggability 0.80
Structure
x-ray diffraction · 7 distinct chains · 36% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Tyrosine-protein kinase JAK2 (EC 2.7.10.2) | protein | 441 | 34% helix, 27% strand | O60674 |
| C | Tyrosine-protein kinase JAK2 (EC 2.7.10.2) | protein | 418 | 37% helix, 21% strand | O60674 |
| D | Tyrosine-protein kinase JAK2 (EC 2.7.10.2) | protein | 417 | 36% helix, 22% strand | O60674 |
| E | Tyrosine-protein kinase JAK2 (EC 2.7.10.2) | protein | 427 | 35% helix, 26% strand | O60674 |
| F | Tyrosine-protein kinase JAK2 (EC 2.7.10.2) | protein | 436 | 35% helix, 24% strand | O60674 |
| G | Tyrosine-protein kinase JAK2 (EC 2.7.10.2) | protein | 411 | 37% helix, 23% strand | O60674 |
| H | Tyrosine-protein kinase JAK2 (EC 2.7.10.2) | protein | 405 | 36% helix, 22% strand | O60674 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 390 | 0.80 | 0.89 | 47 | empty |
| 2 | 408 | 0.80 | 0.88 | 52 | empty |
| 3 | 417 | 0.80 | 0.88 | 57 | empty |
| 4 | 421 | 0.80 | 0.88 | 53 | empty |
| 5 | 377 | 0.80 | 0.89 | 51 | empty |
Interfaces
14 interfaces between chains.
- E–F · 1323 Ų buried · 15 hydrogen bonds · protein-protein
- A–B · 1298 Ų buried · 15 hydrogen bonds · protein-protein
- C–D · 1286 Ų buried · 16 hydrogen bonds · protein-protein
- G–H · 1268 Ų buried · 13 hydrogen bonds · protein-protein
- B–G · 788 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 4Z32 · Crystal Structure of the FERM-SH2 Domains of Jak2 · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O60674
- Elsewhere: RCSB PDB 4Z32 · PDBe 4Z32 · UniProt O60674
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