Research workbench
Crystal structure of a RNA binding domain of a U2 small nuclear ribonucleoprotein auxiliary factor 2 (U2AF) from mouse at 2.15 a resolution
Analyse Crystal structure of a RNA binding domain of a U2 small nuclear… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4Z2X
- Type
- protein
- Length
- 206 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Splicing factor U2AF 65 kda subunit
- UniProt
- P26369
- Pockets
- 2 · best druggability 0.44
Structure
x-ray diffraction · 2 distinct chains · 34% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Splicing factor U2AF 65 kda subunit | protein | 104 | 34% helix, 25% strand | P26369 |
| B | Splicing factor U2AF 65 kda subunit | protein | 102 | 34% helix, 24% strand | P26369 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 116 | 0.44 | 0.78 | 23 | empty |
| 2 | 63 | 0.44 | 0.82 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 533 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 4Z2X · Crystal structure of a RNA binding domain of a U2 small nuclear ribonucleoprotein… · the same entry in another collection · chain A against A, TM-score 1.00
- P26369 · AlphaFold monomer V2.0 prediction for splicing factor U2AF 65 kda subunit (P26369) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P26369
- Elsewhere: RCSB PDB 4Z2X · PDBe 4Z2X · UniProt P26369
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