Research workbench
Thermostable enolase from chloroflexus aurantiacus
Analyse Thermostable enolase from chloroflexus aurantiacus in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4Z17
- Type
- protein
- Length
- 844 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Enolase
- EC
- 4.2.1.11
- UniProt
- A9WCM4
- Ligands
- PEP, MG
- Pockets
- 10 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 41% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Enolase (EC 4.2.1.11) | protein | 424 | 42% helix, 18% strand | A9WCM4 |
| B | Enolase (EC 4.2.1.11) | protein | 420 | 41% helix, 17% strand | A9WCM4 |
Ligands and binding sites
- PEP · Phosphoenolpyruvate · ligand · 2 copies · chains A, B
- MG · Magnesium ion · metal · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 611 | 0.74 | 0.81 | 62 | MG, PEP |
| 2 | 990 | 0.73 | 0.77 | 53 | empty |
| 3 | 296 | 0.70 | 0.85 | 43 | MG, PEP |
| 4 | 156 | 0.59 | 0.83 | 34 | empty |
| 5 | 144 | 0.53 | 0.80 | 32 | empty |
Interfaces
1 interface between chains.
- A–B · 1875 Ų buried · 30 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A9WCM4
- Elsewhere: RCSB PDB 4Z17 · PDBe 4Z17 · UniProt A9WCM4
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