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Crystal structure of fvo strain plasmodium falciparum AMA1 in complex with the RON2HP [THR2040ALA] peptide
Analyse Crystal structure of fvo strain plasmodium falciparum AMA1 in complex with the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4Z09
- Type
- protein
- Length
- 283 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Apical membrane antigen 1; Rhoptry neck protein 2
- UniProt
- A0A024UZE1
- Pockets
- 1 · best druggability 0.27
Structure
x-ray diffraction · 2 distinct chains · 15% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Apical membrane antigen 1 | protein | 270 | 16% helix, 31% strand | A0A024UZE1 |
| C | Rhoptry neck protein 2 | protein | 13 | 0% helix, 38% strand | — |
Ligands and binding sites
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 61 | 0.27 | 0.72 | 14 | empty |
Interfaces
1 interface between chains.
- A–C · 609 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 4Z09 · Crystal structure of FVO strain Plasmodium falciparum AMA1 in complex with the RON2hp… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A024UZE1
- Elsewhere: RCSB PDB 4Z09 · PDBe 4Z09 · UniProt A0A024UZE1
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