Research workbench

X-ray structure of helicobacter pylori cagl-K74

Analyse X-ray structure of helicobacter pylori cagl-K74 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4YVM
Type: protein
Length: 406 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cag pathogenicity island protein
UniProt: Q75XL3
Pockets: 5 · best druggability 0.60

Structure

x-ray diffraction · 2 distinct chains · 83% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cag pathogenicity island protein	protein	202	83% helix, 0% strand	Q75XL3
B	Cag pathogenicity island protein	protein	204	83% helix, 0% strand	Q75XL3

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	469	0.60	0.74	36	empty
2	419	0.57	0.74	34	empty
3	66	0.50	0.84	16	empty
4	68	0.34	0.76	15	empty
5	50	0.24	0.72	11	empty

Interfaces

1 interface between chains.

A–B · 1778 Å² buried · 23 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

4YVM · X-ray structure of Helicobacter pylori CagL-K74 · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q75XL3
Elsewhere: RCSB PDB 4YVM · PDBe 4YVM · UniProt Q75XL3

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