Research workbench
Structure of the KOW2-KOW3 domain of transcription elongation factor SPT5.
Analyse Structure of the KOW2-KOW3 domain of transcription elongation factor SPT5. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4YTL
- Type
- protein
- Length
- 198 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcription elongation factor SPT5
- UniProt
- P27692
- Ligands
- SO4
- Pockets
- 2 · best druggability 0.52
Structure
x-ray diffraction · 1 distinct chain · 6% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Transcription elongation factor SPT5 | protein | 99 | 6% helix, 51% strand | P27692 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 241 | 0.52 | 0.76 | 39 | GOL |
| 2 | 67 | 0.40 | 0.80 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 722 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 modified (engineered).
Compared structures
- 4YTL · Structure of the KOW2-KOW3 Domain of Transcription Elongation Factor Spt5. · the same entry in another collection · chain A against A, TM-score 1.00
- P27692 · AlphaFold monomer V2.0 prediction for transcription elongation factor SPT5 (P27692) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P27692
- Elsewhere: RCSB PDB 4YTL · PDBe 4YTL · UniProt P27692
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