Research workbench
Enteroaggregative escherichia COLI tssa N-terminal fragment
Analyse Enteroaggregative escherichia COLI tssa N-terminal fragment in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4YO3
- Type
- protein
- Length
- 1,884 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tssa
- UniProt
- B7LFT5
- Pockets
- 20 · best druggability 0.82
Structure
x-ray diffraction · 1 distinct chain · 62% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L | Tssa | protein | 157 | 62% helix, 3% strand | B7LFT5 |
Pockets
20 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1079 | 0.82 | 0.83 | 97 | empty |
| 2 | 1012 | 0.72 | 0.76 | 70 | empty |
| 3 | 680 | 0.72 | 0.79 | 77 | empty |
| 4 | 549 | 0.70 | 0.79 | 63 | empty |
| 5 | 498 | 0.70 | 0.80 | 69 | empty |
Interfaces
14 interfaces between chains.
- J–K · 1487 Ų buried · 16 hydrogen bonds · protein-protein
- F–G · 1483 Ų buried · 16 hydrogen bonds · protein-protein
- H–I · 1471 Ų buried · 13 hydrogen bonds · protein-protein
- B–C · 1464 Ų buried · 12 hydrogen bonds · protein-protein
- D–E · 1450 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 48 modified (engineered).
Compared structures
- 4YO3 · Enteroaggregative Escherichia Coli TssA N-terminal fragment · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B7LFT5
- Elsewhere: RCSB PDB 4YO3 · PDBe 4YO3 · UniProt B7LFT5
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