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Structural insight reveals dynamics in repeating R(CAG) transcript found in HUNTINGTON'S disease (hd) and spinocerebellar ataxias (scas)

Analyse Structural insight reveals dynamics in repeating R(CAG) transcript found in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4YN6
Type: RNA
Length: 38 nucleotides
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA (5'- R(P*UP*UP*GP*GP*GP*CP*CP*AP*GP*CP*AP*GP*CP*AP*GP*GP*UP*CP*C)-3')
Ligands: PO4
Pockets: 1 · best druggability 0.60

Structure

x-ray diffraction · 1 distinct chain.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	RNA (5'- R(PUPUPGPGPGPCPCPAPGPCPAPGPCPAPGPGPUPCP*C)-3')	rna	19	—	—

Ligands and binding sites

PO4 · Phosphate ion · ion · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	542	0.60	0.75	30	empty

Interfaces

1 interface between chains.

A–B · 1075 Å² buried · 91 hydrogen bonds · nucleic-nucleic

Compared structures

4YN6 · Structural Insight reveals dynamics in repeating r(CAG) transcript found in Huntington's… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 4YN6 · PDBe 4YN6

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