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Crystal structure of the domain swapped PXB/TPR domain of mouse SNX21

Analyse Crystal structure of the domain swapped PXB/TPR domain of mouse SNX21 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4YMR
Type: protein
Length: 263 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein SNX21
UniProt: Q3UR97
Pockets: 2 · best druggability 0.72

Structure

x-ray diffraction · 2 distinct chains · 70% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein SNX21	protein	134	69% helix, 0% strand	Q3UR97
B	Protein SNX21	protein	129	71% helix, 0% strand	Q3UR97

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	585	0.72	0.80	59	empty
2	74	0.34	0.75	15	empty

Interfaces

1 interface between chains.

A–B · 2330 Å² buried · 20 hydrogen bonds · protein-protein

Compared structures

4YMR · Crystal structure of the domain swapped PXB/TPR domain of mouse SNX21 · the same entry in another collection · chain A against A, TM-score 1.00
Q3UR97 · AlphaFold monomer V2.0 prediction for sorting nexin-21 (Q3UR97) · a predicted model of the same protein · chain A against A, TM-score 0.55

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q3UR97
Elsewhere: RCSB PDB 4YMR · PDBe 4YMR · UniProt Q3UR97

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