Research workbench
Crystal structure of A102D mutant of HSP14.1 from sulfolobus solfatataricus P2
Analyse Crystal structure of A102D mutant of HSP14.1 from sulfolobus solfatataricus P2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4YLB
- Type
- protein
- Length
- 491 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heat shock protein HSP20
- UniProt
- D0KNS6
- Ligands
- CL
- Pockets
- 5 · best druggability 0.63
Structure
x-ray diffraction · 4 distinct chains · 15% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Heat shock protein HSP20 | protein | 128 | 19% helix, 41% strand | D0KNS6 |
| B | Heat shock protein HSP20 | protein | 117 | 14% helix, 43% strand | D0KNS6 |
| C | Heat shock protein HSP20 | protein | 127 | 13% helix, 40% strand | D0KNS6 |
| D | Heat shock protein HSP20 | protein | 119 | 15% helix, 39% strand | D0KNS6 |
Ligands and binding sites
- CL · Chloride ion · ion · 3 copies · chains A, B, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 522 | 0.63 | 0.76 | 58 | empty |
| 2 | 76 | 0.55 | 0.86 | 27 | empty |
| 3 | 65 | 0.30 | 0.74 | 17 | empty |
| 4 | 74 | 0.28 | 0.72 | 19 | empty |
| 5 | 54 | 0.26 | 0.74 | 19 | empty |
Interfaces
5 interfaces between chains.
- C–D · 1974 Ų buried · 40 hydrogen bonds · protein-protein
- A–B · 1965 Ų buried · 42 hydrogen bonds · protein-protein
- A–C · 942 Ų buried · 14 hydrogen bonds · protein-protein
- A–D · 370 Ų buried · 2 hydrogen bonds · protein-protein
- B–C · 367 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 4YLB · Crystal Structure of A102D mutant of hsp14.1 from Sulfolobus solfatataricus P2 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt D0KNS6
- Elsewhere: RCSB PDB 4YLB · PDBe 4YLB · UniProt D0KNS6
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.