Research workbench
Structure of the CEACAM6-CEACAM8 heterodimer
Analyse Structure of the CEACAM6-CEACAM8 heterodimer in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4YIQ
- Type
- protein
- Length
- 429 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Carcinoembryonic antigen-related cell adhesion molecule 8; Carcinoembryonic…
- UniProt
- P31997, P40199
- Ligands
- CL
- Pockets
- 2 · best druggability 0.67
Structure
x-ray diffraction · 3 distinct chains · 6% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Carcinoembryonic antigen-related cell adhesion molecule 8 | protein | 107 | 6% helix, 50% strand | P31997 |
| B | Carcinoembryonic antigen-related cell adhesion molecule 6 | protein | 107 | 6% helix, 51% strand | P40199 |
| D | Carcinoembryonic antigen-related cell adhesion molecule 6 | protein | 108 | 6% helix, 51% strand | P40199 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 503 | 0.67 | 0.78 | 58 | empty |
| 2 | 153 | 0.43 | 0.75 | 23 | empty |
Interfaces
4 interfaces between chains.
- C–D · 749 Ų buried · 8 hydrogen bonds · protein-protein
- A–B · 740 Ų buried · 8 hydrogen bonds · protein-protein
- C–B · 334 Ų buried · 1 hydrogen bond · protein-protein
- A–C · 112 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4YIQ · Structure of the CEACAM6-CEACAM8 heterodimer · the same entry in another collection · chain D against D, TM-score 1.00
- P31997 · AlphaFold monomer V2.0 prediction for carcinoembryonic antigen- related cell adhesion… · a predicted model of the same protein · chain A against A, TM-score 0.99
- P40199 · AlphaFold monomer V2.0 prediction for carcinoembryonic antigen- related cell adhesion… · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P31997
- Every structure of UniProt P40199
- Elsewhere: RCSB PDB 4YIQ · PDBe 4YIQ · UniProt P31997 · UniProt P40199
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