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Structure of the synthetic duffy binding protein (dbp) antigen deknull relevant for malaria vaccine design

Analyse Structure of the synthetic duffy binding protein (dbp) antigen deknull relevant… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4YFS
Type: protein
Length: 285 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Duffy receptor
UniProt: P22290
Pockets: 3 · best druggability 0.72

Structure

x-ray diffraction · 1 distinct chain · 67% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Duffy receptor	protein	285	67% helix, 1% strand	P22290

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	92	0.72	0.95	22	empty
2	73	0.34	0.75	17	empty
3	62	0.29	0.74	16	empty

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

4YFS · Structure of the synthetic Duffy Binding Protein (DBP) antigen DEKnull relevant for… · the same entry in another collection · chain A against A, TM-score 1.00
P22290 · AlphaFold monomer V2.0 prediction for duffy receptor (P22290) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P22290
Elsewhere: RCSB PDB 4YFS · PDBe 4YFS · UniProt P22290

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