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The crystal structure of the intact human glnrs

Analyse The crystal structure of the intact human glnrs in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4YE6
Type: protein
Length: 709 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glutamine--tRNA ligase
EC: 6.1.1.18
UniProt: P47897
Pockets: 8 · best druggability 0.70

Structure

x-ray diffraction · 1 distinct chain · 38% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Glutamine--tRNA ligase (EC 6.1.1.18)	protein	709	38% helix, 15% strand	P47897

Pockets

8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	442	0.70	0.81	45	empty
2	349	0.63	0.79	51	empty
3	359	0.56	0.74	41	empty
4	104	0.55	0.84	28	empty
5	105	0.55	0.84	22	empty

Compared structures

4YE6 · The crystal structure of the intact human GlnRS · the same entry in another collection · chain A against A, TM-score 1.00
P47897 · AlphaFold monomer V2.0 prediction for glutamine--tRNA ligase (P47897) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P47897
Elsewhere: RCSB PDB 4YE6 · PDBe 4YE6 · UniProt P47897

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