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Crystal structure of a novel alanine-zipper trimer at 1.3 a resolution, I6A,L9A,V13A,L16A,V20A,L23A,V27A,M30A,V34A,L48A,M51A mutations

Analyse Crystal structure of a novel alanine-zipper trimer at 1.3 a resolution… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1JCD
Type: protein
Length: 152 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Major outer membrane lipoprotein
UniProt: P69776
Pockets: 1 · best druggability 0.30

Structure

x-ray diffraction · 2 distinct chains · 93% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C	Major outer membrane lipoprotein	protein	50	94% helix, 0% strand	P69776
B	Major outer membrane lipoprotein	protein	52	92% helix, 0% strand	P69776

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	50	0.30	0.77	15	empty

Interfaces

3 interfaces between chains.

A–B · 1026 Å² buried · 20 hydrogen bonds · protein-protein
A–C · 970 Å² buried · 15 hydrogen bonds · protein-protein
B–C · 814 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

1JCD · Crystal Structure of a Novel Alanine-Zipper Trimer at 1.3 A Resolution… · the same entry in another collection · chain A against A, TM-score 1.00
P69776 · AlphaFold monomer V2.0 prediction for major outer membrane lipoprotein lpp (P69776) · a predicted model of the same protein · chain A against A, TM-score 0.88

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P69776
Elsewhere: RCSB PDB 1JCD · PDBe 1JCD · UniProt P69776

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