Crystal structure of glucosyl-3-phosphoglycerate synthase from mycobacterium tuberculosis in complex with MN2+, uridine-diphosphate- glucose (udp-glc) and phosphoglyceric acid (pga) - gpgs MN2+ udp-glc pga-3

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 17% strand (DSSP).

Ligands and binding sites

• 3PG · 3-phosphoglyceric acid · ligand · chains A
• UPG · Uridine-5'-diphosphate-glucose · ligand · chains A
• MN · Manganese (II) ion · metal · chains A
• CL · Chloride ion · ion · chains A
• EDO · 1,2-ethanediol · additive · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Compared structures

• 4Y9X · Crystal structure of glucosyl-3-phosphoglycerate synthase from Mycobacterium tuberculosis… · the same entry in another collection · chain A against A, TM-score 1.00
• P9WMW9 · AlphaFold monomer V2.0 prediction for glucosyl-3-phosphoglycerate synthase (P9WMW9) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P9WMW9
• Elsewhere: RCSB PDB 4Y9X · PDBe 4Y9X · UniProt P9WMW9