Research workbench
Structure of an H300N mutant of potato epoxide hydrolase, STEH1
Analyse Structure of an H300N mutant of potato epoxide hydrolase, STEH1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4Y9S
- Type
- protein
- Length
- 639 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Epoxide hydrolase
- UniProt
- Q41415
- Pockets
- 4 · best druggability 0.79
Structure
x-ray diffraction · 2 distinct chains · 44% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Epoxide hydrolase | protein | 320 | 44% helix, 16% strand | Q41415 |
| B | Epoxide hydrolase | protein | 319 | 45% helix, 16% strand | Q41415 |
Pockets
4 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 521 | 0.79 | 0.85 | 51 | empty |
| 2 | 432 | 0.78 | 0.86 | 43 | empty |
| 3 | 51 | 0.68 | 0.97 | 16 | empty |
| 4 | 428 | 0.65 | 0.78 | 55 | empty |
Interfaces
1 interface between chains.
- A–B · 575 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 4Y9S · structure of an H300N mutant of potato epoxide hydrolase, StEH1 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q41415
- Elsewhere: RCSB PDB 4Y9S · PDBe 4Y9S · UniProt Q41415
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