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The crystal structure of hazara virus nucleoprotein
Analyse The crystal structure of hazara virus nucleoprotein in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4XZE
- Type
- protein
- Length
- 1,885 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nucleoprotein
- UniProt
- M4PWE6
- Pockets
- 20 · best druggability 0.85
Structure
x-ray diffraction · 4 distinct chains · 58% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nucleoprotein | protein | 472 | 58% helix, 3% strand | M4PWE6 |
| B | Nucleoprotein | protein | 473 | 60% helix, 3% strand | M4PWE6 |
| C | Nucleoprotein | protein | 474 | 58% helix, 3% strand | M4PWE6 |
| D | Nucleoprotein | protein | 466 | 58% helix, 2% strand | M4PWE6 |
Pockets
20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1104 | 0.85 | 0.86 | 86 | empty |
| 2 | 1127 | 0.85 | 0.86 | 97 | empty |
| 3 | 1033 | 0.83 | 0.84 | 73 | empty |
| 4 | 1089 | 0.82 | 0.83 | 78 | empty |
| 5 | 262 | 0.69 | 0.84 | 24 | empty |
Interfaces
5 interfaces between chains.
- A–B · 1078 Ų buried · 3 hydrogen bonds · protein-protein
- B–D · 897 Ų buried · 6 hydrogen bonds · protein-protein
- A–C · 888 Ų buried · 5 hydrogen bonds · protein-protein
- B–C · 45 Ų buried · 0 hydrogen bonds · protein-protein
- A–D · 12 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4XZE · The crystal structure of Hazara virus nucleoprotein · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt M4PWE6
- Elsewhere: RCSB PDB 4XZE · PDBe 4XZE · UniProt M4PWE6
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