Research workbench
MIS16 with H4 peptide
Analyse MIS16 with H4 peptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4XYI
- Type
- protein
- Length
- 388 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Kinetochore protein MIS16; Histone H4
- UniProt
- B6K598, B6JV96
- Pockets
- 4 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 13% helix, 42% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Kinetochore protein MIS16 | protein | 375 | 11% helix, 43% strand | B6K598 |
| B | Histone H4 | protein | 13 | 77% helix, 0% strand | B6JV96 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 471 | 0.77 | 0.85 | 38 | empty |
| 2 | 170 | 0.51 | 0.78 | 22 | empty |
| 3 | 98 | 0.39 | 0.76 | 17 | empty |
| 4 | 77 | 0.38 | 0.78 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 654 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 4XYI · Mis16 with H4 peptide · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B6K598
- Every structure of UniProt B6JV96
- Elsewhere: RCSB PDB 4XYI · PDBe 4XYI · UniProt B6K598 · UniProt B6JV96
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