Research workbench
Crystal structure of the spry domain of the human dead-box protein DDX1
Analyse Crystal structure of the spry domain of the human dead-box protein DDX1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4XW3
- Type
- protein
- Length
- 384 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATP-dependent RNA helicase DDX1
- UniProt
- A3RJH1
- Pockets
- 4 · best druggability 0.53
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | ATP-dependent RNA helicase DDX1 | protein | 190 | 5% helix, 47% strand | A3RJH1 |
| B | ATP-dependent RNA helicase DDX1 | protein | 194 | 8% helix, 46% strand | A3RJH1 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 96 | 0.53 | 0.84 | 21 | empty |
| 2 | 54 | 0.36 | 0.80 | 14 | empty |
| 3 | 50 | 0.36 | 0.80 | 24 | empty |
| 4 | 70 | 0.34 | 0.76 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 572 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 4XW3 · Crystal structure of the SPRY domain of the human DEAD-box protein DDX1 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A3RJH1
- Elsewhere: RCSB PDB 4XW3 · PDBe 4XW3 · UniProt A3RJH1
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