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Structure of the hepatitis C virus envelope glycoprotein E2 antigenic 2 region 412-423 bound to the broadly neutralizing antibody HC33.1
Analyse Structure of the hepatitis C virus envelope glycoprotein E2 antigenic 2 region… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4XVJ
- Type
- protein
- Length
- 264 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- HCV E2 antigen; Antibody heavy chain variable domain; Antibody light chain variable domain
- Pockets
- 1 · best druggability 0.45
Structure
x-ray diffraction · 3 distinct chains · 4% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | HCV E2 antigen | protein | 13 | 0% helix, 15% strand | — |
| H | Antibody heavy chain variable domain | protein | 137 | 2% helix, 50% strand | — |
| L | Antibody light chain variable domain | protein | 114 | 7% helix, 46% strand | — |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 166 | 0.45 | 0.75 | 30 | empty |
Interfaces
3 interfaces between chains.
- H–L · 927 Ų buried · 10 hydrogen bonds · protein-protein
- A–H · 821 Ų buried · 15 hydrogen bonds · protein-protein
- A–L · 209 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 4XVJ · Structure of the hepatitis C virus envelope glycoprotein E2 antigenic 2 region 412-423… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 4XVJ · PDBe 4XVJ
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