Research workbench
Heterodimeric complex of transcription factors MEIS1 and DLX3 on specific DNA
Analyse Heterodimeric complex of transcription factors MEIS1 and DLX3 on specific DNA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4XRS
- Type
- protein + DNA
- Length
- 292 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA (5'-D(P*CP*AP*AP*TP*TP*AP*TP*CP*CP*TP*GP*TP*CP*AP*A)- 3'); DNA (5'…
- UniProt
- O00470, O60479
- Pockets
- 10 · best druggability 0.79
Structure
x-ray diffraction · 7 distinct chains · 39% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| M | DNA (5'-D(P*CP*AP*AP*TP*TP*AP*TP*CP*CP*TP*GP*TP*CP*AP*A)- 3') | dna | 15 | — | — |
| D | DNA (5'- D(P*AP*CP*AP*AP*TP*TP*AP*TP*CP*CP*TP*GP*TP*CP*AP*AP*C)-3') | dna | 17 | — | — |
| E | DNA (5'- D(P*GP*TP*TP*GP*AP*CP*AP*GP*GP*AP*TP*AP*AP*TP*TP*GP*TP*T)-3') | dna | 18 | — | — |
| L | DNA (5'- D(P*TP*TP*GP*AP*CP*AP*GP*GP*AP*TP*AP*AP*TP*TP*GP*T)-3') | dna | 16 | — | — |
| A | Homeobox protein MEIS1 | protein | 56 | 32% helix, 0% strand | O00470 |
| B | Homeobox protein MEIS1 | protein | 58 | 48% helix, 0% strand | O00470 |
| G, I | Homeobox protein dlx-3 | protein | 56 | 36% helix, 0% strand | O60479 |
Pockets
10 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1182 | 0.79 | 0.81 | 102 | empty |
| 2 | 72 | 0.66 | 0.93 | 16 | empty |
| 3 | 140 | 0.61 | 0.85 | 25 | empty |
| 4 | 309 | 0.59 | 0.78 | 23 | empty |
| 5 | 204 | 0.56 | 0.79 | 23 | empty |
Interfaces
14 interfaces between chains.
- D–E · 754 Ų buried · 42 hydrogen bonds · nucleic-nucleic
- M–L · 639 Ų buried · 38 hydrogen bonds · nucleic-nucleic
- E–I · 454 Ų buried · 15 hydrogen bonds · protein-nucleic
- L–G · 405 Ų buried · 17 hydrogen bonds · protein-nucleic
- E–B · 327 Ų buried · 7 hydrogen bonds · protein-nucleic
Compared structures
- 4XRS · Heterodimeric complex of transcription factors MEIS1 and DLX3 on specific DNA · the same entry in another collection · chain I against I, TM-score 1.00
- O00470 · AlphaFold monomer V2.0 prediction for homeobox protein MEIS1 (O00470) · a predicted model of the same protein · chain A against A, TM-score 0.75
- O60479 · AlphaFold monomer V2.0 prediction for homeobox protein dlx-3 (O60479) · a predicted model of the same protein · chain G against A, TM-score 0.67
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O00470
- Every structure of UniProt O60479
- Elsewhere: RCSB PDB 4XRS · PDBe 4XRS · UniProt O00470 · UniProt O60479
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