Research workbench
Central domain of mycoplasma genitalium terminal organelle protein MG491
Analyse Central domain of mycoplasma genitalium terminal organelle protein MG491 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4XNG
- Type
- protein
- Length
- 559 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Uncharacterized protein MG218.1
- UniProt
- Q9ZB78
- Pockets
- 12 · best druggability 0.85
Structure
x-ray diffraction · 4 distinct chains · 78% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Uncharacterized protein MG218.1 | protein | 140 | 79% helix, 0% strand | Q9ZB78 |
| B | Uncharacterized protein MG218.1 | protein | 137 | 80% helix, 0% strand | Q9ZB78 |
| C | Uncharacterized protein MG218.1 | protein | 138 | 80% helix, 0% strand | Q9ZB78 |
| D | Uncharacterized protein MG218.1 | protein | 144 | 76% helix, 0% strand | Q9ZB78 |
Pockets
12 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 936 | 0.85 | 0.87 | 105 | empty |
| 2 | 63 | 0.57 | 0.89 | 13 | empty |
| 3 | 58 | 0.57 | 0.89 | 11 | empty |
| 4 | 61 | 0.55 | 0.88 | 17 | empty |
| 5 | 143 | 0.50 | 0.79 | 20 | empty |
Interfaces
5 interfaces between chains.
- A–D · 1326 Ų buried · 14 hydrogen bonds · protein-protein
- B–C · 1230 Ų buried · 15 hydrogen bonds · protein-protein
- C–D · 547 Ų buried · 3 hydrogen bonds · protein-protein
- A–B · 514 Ų buried · 1 hydrogen bond · protein-protein
- A–C · 342 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 modified (engineered).
Compared structures
- 4XNG · Central Domain of Mycoplasma Genitalium Terminal Organelle protein MG491 · the same entry in another collection · chain D against D, TM-score 1.00
- Q9ZB78 · AlphaFold monomer V2.0 prediction for uncharacterized protein MG218.1 (Q9ZB78) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9ZB78
- Elsewhere: RCSB PDB 4XNG · PDBe 4XNG · UniProt Q9ZB78
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