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Crystal structure of C-met in complex with (R)-5-(8-fluoro-3-(1- fluoro-1-(3-methoxyquinolin-6-YL)ETHYL)-[1,2,4]TRIAZOLO[4,3- A]PYRIDIN-6-yl)-3-methylisoxazole

Analyse Crystal structure of C-met in complex with (R)-5-(8-fluoro-3-(1… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4XMO
Type: protein
Length: 289 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hepatocyte growth factor receptor
EC: 2.7.10.1
UniProt: P08581
Ligands: 46G
Pockets: 3 · best druggability 0.64

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Hepatocyte growth factor receptor (EC 2.7.10.1)	protein	289	43% helix, 16% strand	P08581

Ligands and binding sites

46G · 6-{(1R)-1-fluoro-1-[8-fluoro-6-(3-methyl-1,2-oxazol-5-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethyl}-3-methoxyquinoline · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	236	0.64	0.82	28	46G
2	89	0.36	0.75	12	empty
3	80	0.36	0.76	13	empty

Compared structures

4XMO · Crystal structure of c-Met in complex with (R)-5-(8-fluoro-3-(1-fluoro-1-(3-methoxyquinoli… · the same entry in another collection · chain A against A, TM-score 1.00

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Every structure of UniProt P08581
Elsewhere: RCSB PDB 4XMO · PDBe 4XMO · UniProt P08581

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