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Apo structure of kari from ignisphaera aggregans

Analyse Apo structure of kari from ignisphaera aggregans in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4XEH
Type: protein
Length: 326 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ketol-acid reductoisomerase
EC: 1.1.1.86
UniProt: E0SRA9
Pockets: 4 · best druggability 0.53

Structure

x-ray diffraction · 1 distinct chain · 60% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ketol-acid reductoisomerase (EC 1.1.1.86)	protein	326	60% helix, 12% strand	E0SRA9

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	316	0.53	0.74	40	empty
2	282	0.50	0.73	35	empty
3	82	0.35	0.75	20	empty
4	58	0.29	0.74	10	empty

Compared structures

4XEH · Apo structure of KARI from Ignisphaera aggregans · the same entry in another collection · chain A against A, TM-score 1.00
E0SRA9 · AlphaFold monomer V2.0 prediction for ketol-acid reductoisomerase (NAD(P)(+)) (E0SRA9) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt E0SRA9
Elsewhere: RCSB PDB 4XEH · PDBe 4XEH · UniProt E0SRA9

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