Research workbench
Structure of RPF2-RRS1 complex involved in ribosome biogenesis
Analyse Structure of RPF2-RRS1 complex involved in ribosome biogenesis in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4XD9
- Type
- protein
- Length
- 646 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ribosome biogenesis protein, putative (AFU_ORTHOLOGUE AFUA_8G04790); Ribosome biogenesis…
- UniProt
- C8VMF9, Q5B6T5
- Pockets
- 7 · best druggability 0.63
Structure
x-ray diffraction · 3 distinct chains · 25% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Ribosome biogenesis protein, putative (AFU_ORTHOLOGUE AFUA_8G04790) | protein | 236 | 21% helix, 35% strand | C8VMF9 |
| B | Ribosome biogenesis protein (RRS1), putative (AFU_ORTHOLOGUE AFUA_7G04430) | protein | 88 | 30% helix, 18% strand | Q5B6T5 |
| D | Ribosome biogenesis protein (RRS1), putative (AFU_ORTHOLOGUE AFUA_7G04430) | protein | 86 | 30% helix, 19% strand | Q5B6T5 |
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 257 | 0.63 | 0.81 | 30 | empty |
| 2 | 242 | 0.63 | 0.82 | 31 | empty |
| 3 | 328 | 0.57 | 0.76 | 38 | empty |
| 4 | 214 | 0.51 | 0.76 | 29 | empty |
| 5 | 80 | 0.48 | 0.82 | 19 | empty |
Interfaces
3 interfaces between chains.
- A–B · 2780 Ų buried · 34 hydrogen bonds · protein-protein
- C–D · 2711 Ų buried · 38 hydrogen bonds · protein-protein
- B–C · 92 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 4XD9 · Structure of Rpf2-Rrs1 complex involved in ribosome biogenesis · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt C8VMF9
- Every structure of UniProt Q5B6T5
- Elsewhere: RCSB PDB 4XD9 · PDBe 4XD9 · UniProt C8VMF9 · UniProt Q5B6T5
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