X-ray structure of the N-formyltransferase qdtf from providencia alcalifaciens, W305A mutant, in the presence of tdp-QUI3N and N5-thf

Structure

x-ray diffraction · 1 distinct chain · 36% helix, 18% strand (DSSP).

Ligands and binding sites

• FON · N-{[4-({[(6R)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}-L-glutamic acid · ligand · chains A
• T3Q · [(3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl][hydroxy-[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]phosphoryl] hydrogen phosphate · ligand · chains A
• NA · Sodium ion · metal · 4 copies · chains A
• K · Potassium ion · metal
• CL · Chloride ion · ion · 3 copies · chains A
• EDO · 1,2-ethanediol · additive · 5 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Compared structures

• 4XD1 · X-ray structure of the N-formyltransferase QdtF from Providencia alcalifaciens, W305A… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt F8RC03
• Elsewhere: RCSB PDB 4XD1 · PDBe 4XD1 · UniProt F8RC03